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Literature summary for 3.4.24.79 extracted from

  • Pan, H.; Hanada, S.; Zhao, J.; Mao, L.; Ma, M.
    Protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth in vivo (2012), PLoS ONE, 7, e48799.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.79

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor-binding protein-4 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13219
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
Calu-1 cell
-
 Homo sapiens
-
lung cancer cell
-
 Homo sapiens
-
additional information the enzyme is not detected in bronchial epithelial cells Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H1744 cell
-
 Homo sapiens
-
NCI-H1792 cell
-
 Homo sapiens
-
NCI-H460 cell
-
 Homo sapiens
-
NCI-H522 cell
-
 Homo sapiens
-
NCI-H596 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor-binding protein-4 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PAPPA
-
 Homo sapiens
pregnancy-associated plasma protein-A
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction down-regulation of enzyme expression and secretion decreases tumor growth after implanted in vivo Homo sapiens
physiological function protein secretion is required for pregnancy-associated plasma protein-A to promote lung cancer growth and progression in vivo Homo sapiens