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Literature summary for 3.4.24.79 extracted from

  • Bestwick, J.P.; Huttly, W.J.; Wald, N.J.
    First trimester Downs syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free beta human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency (2008), J. Med. Screen., 15, 204-206.
    View publication on PubMed

Application

Application Comment Organism
medicine the effect of smoking on three first trimester screening markers for Down’s syndrome that constitute the Combined test, namely nuchal translucency (NT), PAPP-A and free beta human chorionic gonadotophin is examined. In addition it is determined which of these markers need to be adjusted for smoking and by how much. The effect of adjusting for smoking on the Combined test is small, with an estimated less than 0.5% increase in the detection rate for a 3% false-positive rate and less than 0.2% decrease in the false-positive rate for an 85% detection rate Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
blood
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Homo sapiens
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Synonyms

Synonyms Comment Organism
PAPP-A
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Homo sapiens
pregnancy-associated plasma protein-A
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Homo sapiens