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Literature summary for 3.4.24.79 extracted from

  • Laursen, L.S.; Overgaard, M.T.; Soe, R.; Boldt, H.B.; Sottrup-Jensen, L.; Giudice, L.C.; Conover, C.A.; Oxvig, C.
    Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A (2001), FEBS Lett., 504, 36-40.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
insulin-like growth factor binding protein-4 + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Cleavage of the Met135-/-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser143-/-Lys bond in IGFBP-5 mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
insulin-like growth factor binding protein-4 + H2O
-
 Homo sapiens ?
-
 ?
insulin-like growth factor binding protein-5 + H2O cleavage occurs between Ser143 and Lys144 Homo sapiens ?
-
 ?
additional information cleavage of insulin-like growth factor binding protein-5 does not require insulin-like growth factor Homo sapiens ?
-
 ?
additional information cleavage of insulin-like growth factor binding protein-4 occurs only in presence of insulin-like growth factor-II Homo sapiens ?
-
 ?