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Literature summary for 3.4.24.75 extracted from

  • Johnson, C.T.; Sok, M.C.P.; Martin, K.E.; Kalelkar, P.P.; Caplin, J.D.; Botchwey, E.A.; Garcia, A.J.
    Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects (2019), Sci. Adv., 5, eaaw1228 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine a bone morphogenetic protein 2-loaded lysostaphin-delivering hydrogel simultaneously prevents Staphylococcus aureus infection and repairs nonhealing segmental bone defects in the murine radius Staphylococcus simulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Staphylococcus aureus strain UAMS-1 cell wall + H2O Staphylococcus simulans
-
 ?
-
 ?
Staphylococcus aureus strain Xen29 cell wall + H2O Staphylococcus simulans
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus simulans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Staphylococcus aureus strain UAMS-1 cell wall + H2O
-
 Staphylococcus simulans ?
-
 ?
Staphylococcus aureus strain Xen29 cell wall + H2O
-
 Staphylococcus simulans ?
-
 ?

General Information

General Information Comment Organism
physiological function lysostaphin is an anti-staphylococcal enzyme resulting in bacterial lysis and biofilm reduction Staphylococcus simulans