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Literature summary for 3.4.24.73 extracted from

  • Escalante, T.; Shannon, J.; Moura-da-Silva, A.M.; Gutierrez, J.M.; Fox, J.W.
    Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study (2006), Arch. Biochem. Biophys., 455, 144-153.
    View publication on PubMed
Search for more literature for 3.4.24.73

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Bothrops jararaca
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Bothrops jararaca
additional information the enzyme is a P-III snake venom metalloproteinase Bothrops jararaca

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
 x * 52000, SDS-PAGE Bothrops jararaca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Laminin + H2O Bothrops jararaca degradation ?
-
 ?
additional information Bothrops jararaca the enzyme is a P-III snake venom metalloproteinase and a potent hemorrhagin, it causes capillary vessel basement membrane damage in vitro and in vivo, degradation of extracellular matrix components in skeletal muscle cells and endothelial cells, overview ?
-
 ?
Nidogen + H2O Bothrops jararaca degradation, preferred substrate ?
-
 ?
Type IV collagen + H2O Bothrops jararaca degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bothrops jararaca
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Bothrops jararaca
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
400
-
 purified enzyme Bothrops jararaca

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
azocasein + H2O
-
 Bothrops jararaca ?
-
 ?
Laminin + H2O degradation Bothrops jararaca ?
-
 ?
Laminin + H2O degradation of alpha1, beta1, and gamma1 chains Bothrops jararaca ?
-
 ?
additional information the enzyme is a P-III snake venom metalloproteinase and a potent hemorrhagin, it causes capillary vessel basement membrane damage in vitro and in vivo, degradation of extracellular matrix components in skeletal muscle cells and endothelial cells, overview Bothrops jararaca ?
-
 ?
additional information the snake venom hemorrhagic metalloproteinase causes capillary vessel basement membrane damage in vitro and in vivo, overview Bothrops jararaca ?
-
 ?
Nidogen + H2O degradation, preferred substrate Bothrops jararaca ?
-
 ?
Type IV collagen + H2O degradation Bothrops jararaca ?
-
 ?

Subunits

Subunits Comment Organism
? x * 52000, SDS-PAGE Bothrops jararaca

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bothrops jararaca

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Bothrops jararaca