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Literature summary for 3.4.24.73 extracted from

  • Zigrino, P.; Kamiguti, A.S.; Eble, J.; Drescher, C.; Nischt, R.; Fox, J.W.; Mauch, C.
    The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling (2002), J. Biol. Chem., 277, 40528-40535.
    View publication on PubMed
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Application

Application Comment Organism
medicine useful tool for studying the molecular basis of collagen-induced cellular activities in human skin fibroblasts for comparison and contrast with other cell types Bothrops jararaca

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bothrops jararaca jararhagin blocks type I collagen-induced platelet aggregation by binding to the alpha2beta1 integrin and inhibiting collagen-mediated intracellular signaling events, in contrast to observation in platelets enzyme binding to the integrin receptor alpha2beta1 in fibroblasts produces collagen-like cell signaling events such as up-regulation of matrix metalloproteinase-1 and membrane-type matrix metalloproteinase-1, in fibroblasts enzyme functions as a collagen-mimetic substrate that binds to and activates integrins ?
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Organism

Organism UniProt Comment Textmining
Bothrops jararaca
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 snake
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information jararhagin blocks type I collagen-induced platelet aggregation by binding to the alpha2beta1 integrin and inhibiting collagen-mediated intracellular signaling events, in contrast to observation in platelets enzyme binding to the integrin receptor alpha2beta1 in fibroblasts produces collagen-like cell signaling events such as up-regulation of matrix metalloproteinase-1 and membrane-type matrix metalloproteinase-1, in fibroblasts enzyme functions as a collagen-mimetic substrate that binds to and activates integrins Bothrops jararaca ?
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