Application | Comment | Organism |
---|---|---|
pharmacology | alfimeprase is a potential therapeutic agents in thrombosis therapy, clinical indications and studies, overview | Agkistrodon contortrix contortrix |
Cloned (Comment) | Organism |
---|---|
expression of the wild-type fibrolase and a truncated enzyme form, alfimeprase | Agkistrodon contortrix contortrix |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha2-Macroglobulin | rapid, irreversible inhibition by physical entrapment | Agkistrodon contortrix contortrix |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Agkistrodon contortrix contortrix | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Agkistrodon contortrix contortrix | |
Zn2+ | the zinc binding region spans amino acids 139-159 | Agkistrodon contortrix contortrix |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrin + H2O | Agkistrodon contortrix contortrix | fibrinolytic activity | ? | - |
? | |
fibrinogen + H2O | Agkistrodon contortrix contortrix | fibrinogenolytic activity | fibrin + propeptide | - |
? | |
additional information | Agkistrodon contortrix contortrix | thrombolysis in animals by snake venom alfimeprase, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Agkistrodon contortrix contortrix | - |
southern copperhead snake | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Agkistrodon contortrix contortrix | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
blood clot lysis in vitro model, overview | Agkistrodon contortrix contortrix |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fibrin + H2O | fibrinolytic activity | Agkistrodon contortrix contortrix | ? | - |
? | |
Fibrin + H2O | fibrinolytic activity cleaving the Lys413-Leu414 bond | Agkistrodon contortrix contortrix | ? | - |
? | |
fibrinogen + H2O | fibrinogenolytic activity | Agkistrodon contortrix contortrix | fibrin + propeptide | - |
? | |
fibrinogen + H2O | human substrate, fibrinogenolytic activity | Agkistrodon contortrix contortrix | fibrin + propeptide | - |
? | |
additional information | thrombolysis in animals by snake venom alfimeprase, overview | Agkistrodon contortrix contortrix | ? | - |
? | |
additional information | alfimeprase is the recombinant truncated form of fibrolase from snake venom lacking the two N-terminal amino acids Glu and Gln | Agkistrodon contortrix contortrix | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | alfimeprase is the recombinant truncated form of fibrolase from snake venom lacking the two N-terminal amino acids Glu and Gln, fibrolase N-terminus: SFPQR, alfimeprase N-terminus: EQRFPQR | Agkistrodon contortrix contortrix |
Synonyms | Comment | Organism |
---|---|---|
Alfimeprase | - |
Agkistrodon contortrix contortrix |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Agkistrodon contortrix contortrix |