Any feedback?
Literature summary for 3.4.24.71 extracted from
- Endothelin-converting enzyme-1 regulates glucagon-like peptide-1 receptor signalling and resensitisation (2019), Biochem. J., 476, 513-533 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| SM19712 | selective inhibitor, 0.01 mM used in inhibition assay conditions | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | Homo sapiens | - |
endothelin-1 + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P42892 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | - |
Homo sapiens | endothelin-1 + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Homo sapiens |
| endothelin-converting enzyme-1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme inhibition increases glucagon-like peptide 1-induced activation of extracellular signal-regulated kinase and generation of cAMP. Enzyme inhibition blocks resensitisation of glucagon-like peptide 1 7-36 amide-mediated Ca2+ signalling | Homo sapiens |
| metabolism | the enzyme regulates glucagon-like peptide-1 receptor signalling and resensitisation | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
