Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of ECE-1a or 1b in CHO cells results in a 75-90% reduction in Abeta1-40 and a 45-60% reduction in Abeta1-42, completely abolished by treatment with phosphoramidon | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by thiorphan and captopril | Homo sapiens | |
PD069185 | a more selective ECE inhibitor | Homo sapiens | |
phosphoramidon | a metalloproteinase inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | ECEs are type II integral membrane-bound proteases | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | ECE-1 is a zinc metallopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide + H2O | Homo sapiens | - |
? | - |
? | |
big endothelin + H2O | Homo sapiens | - |
endothelin 1 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
4 variants of isozyme ECE-1, ECE-1a, 1b, 1c and 1d | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | lower expression of ECE-1 | Homo sapiens | - |
brain | expression analysis of ECE-1 in the temporal cortex of patients with Alzheimer's disease, vascular dementia, and controls, overview. ECE-1 occurs in vascular endothelial cells. ECE-1 mRNA or protein levels, of either full-length ECE-1 or soluble spliced variant, ECE-1sv, in Alzheimer's disease or vascular dementia show no differences compared to controls | Homo sapiens | - |
cerebellar Purkinje cell | cerebellar, lower expression of ECE-1 | Homo sapiens | - |
endothelial cell | ECE-1 | Homo sapiens | - |
H4 neuroglioma cell | - |
Homo sapiens | - |
additional information | ECE-1 immunohistochemic analysis, overview | Homo sapiens | - |
neuron | ECE-1 occurs in neurons in the cerebral cortex, hippocampus, amygdala, basal forebrain nuclei, diencephalon, brain stem and cerebellar hemisphere | Homo sapiens | - |
neuron | ECE-2 | Homo sapiens | - |
pyramidal neuron | lower expression of ECE-1 | Homo sapiens | - |
umbilical vein endothelial cell | i.e. HUVECs, high levels of endogenous ECE | Homo sapiens | - |
vascular endothelial cell | ECE-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta peptide + H2O | - |
Homo sapiens | ? | - |
? | |
big endothelin + H2O | - |
Homo sapiens | endothelin 1 + ? | - |
? | |
big endothelin + H2O | ECE-1a, 1b, 1c and 1d are all equally active on endothelin | Homo sapiens | endothelin 1 + ? | - |
? | |
bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
insulin B chain + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | ECEs can hydrolyze several other biologically active peptides in vitro by cleavage on the amino side of hydrophobic residues | Homo sapiens | ? | - |
? | |
neurotensin + H2O | - |
Homo sapiens | ? | - |
? | |
Substance P + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
endothelin-converting enzyme-1 | - |
Homo sapiens |
More | endothelin-converting enzymes are a class of type II integral membrane-bound proteases, belonging to the M13 family of zinc metallopeptidases | Homo sapiens |