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Literature summary for 3.4.24.71 extracted from
- Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling (2009), J. Biol. Chem., 284, 22411-22425.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GFP-tagged ECE-1 overexpression in HEK-293 cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | ECE-1 overexpression attenuates ERK2 activation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death | Homo sapiens | |
| additional information | ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death | Rattus norvegicus | |
| SM-19712 | a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal | Homo sapiens |  |
| SM-19712 | a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal | Mus musculus | |
| SM-19712 | a specific ECE-1 inhibitor. SM-191712 causes sustained ERK2 activation in cytosolic and nuclear fractions after substance P removal | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| endosome | - |
Mus musculus | 5768 | - |
| endosome | - |
Homo sapiens | 5768 | - |
| endosome | - |
Rattus norvegicus | 5768 | - |
| nucleus | - |
Mus musculus | 5634 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | dependent on | Mus musculus | |
| Zn2+ | dependent on | Homo sapiens | |
| Zn2+ | dependent on | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | Mus musculus | - |
endothelin-1 + ? | - |
? | |
| big endothelin + H2O | Homo sapiens | - |
endothelin-1 + ? | - |
? | |
| big endothelin + H2O | Rattus norvegicus | - |
endothelin-1 + ? | - |
? | |
| additional information | Homo sapiens | ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation | ? | - |
? | |
| additional information | Mus musculus | endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling | ? | - |
? | |
| additional information | Rattus norvegicus | endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
male C57Bl6 mice | - |
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin + H2O | - |
Mus musculus | endothelin-1 + ? | - |
? | |
| big endothelin + H2O | - |
Homo sapiens | endothelin-1 + ? | - |
? | |
| big endothelin + H2O | - |
Rattus norvegicus | endothelin-1 + ? | - |
? | |
| additional information | ECE-1 and endosomal acidification regulate the duration of substance P-induced ERK2 activation | Homo sapiens | ? | - |
? | |
| additional information | endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling | Mus musculus | ? | - |
? | |
| additional information | endothelin-converting enzyme-1 degrades substance P in early endosomes of epithelial cells and neurons to destabilize the endosomal mitogen-activated protein kinase signalosome and terminate signaling | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Mus musculus |
| ECE-1 | - |
Homo sapiens |
| ECE-1 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus, whereas ECE-1 overexpression attenuates ERK2 activation. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death | Homo sapiens |
| malfunction | ECE-1 inhibition causes endosomal retention of the substance P neurokinin 1 receptor, beta-arrestins, and Src, resulting in markedly sustained ERK2 activation in the cytosol and nucleus. ECE-1 inhibition also enhances substance P-induced expression and phosphorylation of the nuclear death receptor Nur77, resulting in cell death | Rattus norvegicus |
| metabolism | regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview | Mus musculus |
| metabolism | regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview | Homo sapiens |
| metabolism | regulation of neuropeptide signaling at the cell surface involving ECE-1, detailed overview | Rattus norvegicus |
| physiological function | ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview | Mus musculus |
| physiological function | ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview | Homo sapiens |
| physiological function | ECE-1 regulates the duration and subcellular location of substance P-induced, beta-arrestin-dependent ERK activation, overview | Rattus norvegicus |
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