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Literature summary for 3.4.24.71 extracted from

  • Cattaruzza, F.; Cottrell, G.S.; Vaksman, N.; Bunnett, N.W.
    Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation (2009), Br. J. Pharmacol., 156, 730-739.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.71

Cloned(Commentary)

Cloned (Comment) Organism
ECE-1 is endogenously expressed in HMEC-1 cells (RT-PCR, immunofluorescence) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-chloro-N-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)carbonyl)benzenesulfonamide
-
 Homo sapiens
4-chloro-N-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)carbonyl)benzenesulfonamide
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 ECE-1 regulates re-sensitization of substance P signalling in HMEC-1-NK1 receptor cells Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
ear ECE-1 promotes re-sensitization of SP-induced inflammation Rattus norvegicus
-
HMEC-1 cell
-
 Homo sapiens
-
skin dorsal skin, ECE-1 promotes re-sensitization of SP-induced inflammation Rattus norvegicus
-
urinary bladder ECE-1 promotes re-sensitization of SP-induced inflammation Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
endothelin-converting enzyme 1 (ECE-1)
-
 Homo sapiens
endothelin-converting enzyme 1 (ECE-1)
-
 Rattus norvegicus