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Literature summary for 3.4.24.71 extracted from
- Re-sensitization of neuropeptide receptors: should we stop the recycling? (2009), Br. J. Pharmacol., 156, 728-729.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | ECE-1 is a potential target for the treatment of Alzheimers disease based on its role in amyloid-beta peptide degradation | Homo sapiens |
| drug development | Inhibition of endothelin-1 production by ECE-1 is a promising target for the treatment of cardiovascular disease, but lack of substrate specificity is disadvantageous since inhibition of ECE-1 has impact on other pathways too | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endosome | - |
Homo sapiens | 5768 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta peptide + H2O | Homo sapiens | - |
? | - |
? |  |
| big endothelin-1 + H2O | Homo sapiens | - |
endothelin-1 + ? | - |
? | |
| bradykinin + H2O | Homo sapiens | - |
? | - |
? | |
| Substance P + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| Hydrolysis of the -Trp21-/-Val- bond in big endothelin to form endothelin 1 | ECE-1 promotes the recycling and re-sensitization of NK1 receptors, by degrading endocytosed substance P in endothelial cell endosomes. ECE-1 promotes CGRP and somatostatin receptor recycling | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | ECE-1 is very abundant | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid-beta peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| big endothelin-1 + H2O | - |
Homo sapiens | endothelin-1 + ? | - |
? | |
| bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
| Substance P + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Homo sapiens |
| endothelin-converting enzyme 1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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