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Literature summary for 3.4.24.71 extracted from
- Diabetes and radiocontrast media increase endothelin converting enzyme-1 in the kidney (2008), Kidney Int., 74, 91-100.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | diabetes and radiocontrast media increase medullary, but not cortical endothelin converting enzyme-1 content in the kidney, in vivo, the induction of diabetes or the administration of contrast media rises the enzyme activity 4-5fold, but 15fold when diabetic rats are given contrast media, the in vitro activity is increased 3-4fold, overview | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| preproendothelin-1 + H2O | Rattus norvegicus | - |
endothelin-1 + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
healthy and streptozotocin-induced diabetic rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | medulla and cortex, expression analysis after enzyme induction, overview | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| preproendothelin-1 + H2O | - |
Rattus norvegicus | endothelin-1 + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Rattus norvegicus |
| endothelin-converting enzyme-1 | - |
Rattus norvegicus |
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