Cloned (Comment) | Organism |
---|---|
overexpression of GFP-tagged isozymes in HEK cell endosomes, subcellular localization, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | early | Homo sapiens | 5768 | - |
membrane | endosomal | Homo sapiens | 16020 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | ECE-1 is a metallo-endopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin-I + H2O | Homo sapiens | degradation, no activity with angiotensin-II | ? | - |
? | |
bradykinin + H2O | Homo sapiens | degradation | ? | - |
? | |
calcitonin gene-related peptide + H2O | Homo sapiens | degradation, co-internalization with ECE-1 into early endosomes, calcitonin gene-related peptide degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution into the cytosol, ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, mechanism, overview | ? | - |
? | |
additional information | Homo sapiens | isoforms of endothelin-converting enzyme-1, ECE-1a-d, are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors, ECE-1 does not regulate either the resensitization of receptors for peptides that are not ECE-1 substrates, e.g. angiotensin II, or the recycling of the bradykinin B2 receptor, which transiently interacts with beta-arrestins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
4 isoforms of endothelin-converting enzyme-1, ECE-1a-d | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin-I + H2O | degradation, no activity with angiotensin-II | Homo sapiens | ? | - |
? | |
bradykinin + H2O | degradation | Homo sapiens | ? | - |
? | |
calcitonin gene-related peptide + H2O | degradation | Homo sapiens | ? | - |
? | |
calcitonin gene-related peptide + H2O | degradation, co-internalization with ECE-1 into early endosomes, calcitonin gene-related peptide degradation promotes CLR/RAMP1 recycling and beta-arrestin2 redistribution into the cytosol, ECE-1 inhibition or knockdown traps CLR/RAMP1 and beta-arrestin2 in endosomes and inhibits CLR/RAMP1 recycling and resensitization, whereas ECE-1 overexpression has the opposite effect, mechanism, overview | Homo sapiens | ? | - |
? | |
additional information | isoforms of endothelin-converting enzyme-1, ECE-1a-d, are present in early endosomes, where they degrade neuropeptides and regulate post-endocytic sorting of receptors, ECE-1 does not regulate either the resensitization of receptors for peptides that are not ECE-1 substrates, e.g. angiotensin II, or the recycling of the bradykinin B2 receptor, which transiently interacts with beta-arrestins | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ECE-1 | - |
Homo sapiens |
endothelin-converting enzyme-1 | - |
Homo sapiens |