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Literature summary for 3.4.24.71 extracted from
- Expression and localization of human endothelin-converting enzyme-1 isoforms in symptomatic atherosclerotic disease and saphenous vein (2006), Exp. Biol. Med., 231, 794-801.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | expression and localization of ECE-1 isozymes in symptomatic atherosclerotic disease and saphenous vein, overview | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin-1 + H2O | Homo sapiens | ECE-1 is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin, ET-1 | endothelin + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes ECE-1a-d | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | determination of enzyme expression by immunohistochemical analysis on atherosclerotic and nonatherosclerotic vascular tissue using a combination of ECE-1 isoform-specific antibodies, distinct expression patterns for ECE-1a and ECE-1c, overview | Homo sapiens | - |
| macrophage | from blood, determination of enzyme expression by immunohistochemical analysis using a combination of ECE-1 isoform-specific antibodies, expression of isozymes ECE-1a and ECE-1c | Homo sapiens | - |
| smooth muscle cell | aortic, determination of enzyme expression by immunohistochemical analysis using a combination of ECE-1 isoform-specific antibodies, expression of isozyme ECE-1a | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| big endothelin-1 + H2O | activation | Homo sapiens | endothelin + ? | - |
? | |
| big endothelin-1 + H2O | ECE-1 is a critical enzyme in the production of the potent vasoconstrictor peptide endothelin, ET-1 | Homo sapiens | endothelin + ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ECE-1 | - |
Homo sapiens |
| endothelin converting enzyme-1 | - |
Homo sapiens |
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