Literature summary for 3.4.24.71 extracted from

Hanessian, S.; Gauchet, C.; Charron, G.; Marin, J.; Nakache, P.
Design and synthesis of diversely substituted azacyclic inhibitors of endothelin converting enzyme (2006), J. Org. Chem., 71, 2760-2778.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2R,3R,4R,5R)-(2S)-(4-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)ethyl]-3-isobutyl-5-phosphonopyrrolidine-2-carbonyl-amino)-3-(1H-indol-3-yl)propionic acid	0.01 mM, 91% inhibition of enzyme activity	Homo sapiens
(2R,4S,5R,6R)-(2S)-(5-[2-(1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-yl)ethyl]-4-isobutyl-6-phosphonopiperidine-2-carbonyl-amino)-3-(1H-indol-3-yl)propionic acid	0.01 mM, 98% inhibition of enzyme activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
ECE	-	Homo sapiens
Endothelin-converting enzyme	-	Homo sapiens

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Release 2023.1 (January 2023)