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Literature summary for 3.4.24.7 extracted from

  • Xu, H.; Zhang, H.; Ding, Y.
    Platelet-derived growth factor and stromal cell-derived factor-1 promote the skin wound repairing effect of bone mesenchymal stem cells a key role of matrix metalloproteinase 1 and collagens (2017), Int. J. Clin. Exp. Pathol., 10, 8253-8262 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
additional information platelet-derived growth factor (PDGF) treatment recruits BSMCs to injured sites and strengthens the effect of BMSCs on skin wound by suppressing activity of MMP-1 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen + H2O Rattus norvegicus
-
 ?
-
 ?
Collagen + H2O Rattus norvegicus Sprague-Dawley
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus B5DFD5
-
-
Rattus norvegicus Sprague-Dawley B5DFD5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Rattus norvegicus
-
mesenchymal stem cell of bone marrow Rattus norvegicus
-
skin
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen + H2O
-
 Rattus norvegicus ?
-
 ?
Collagen + H2O
-
 Rattus norvegicus Sprague-Dawley ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase 1
-
 Rattus norvegicus
MMP-1
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism matrix metalloproteinase 1 and collagens play a key role in platelet-derived growth factor (PDGF) and stromal cell-derived factor-1 (SDF-1) promotion of the skin wound repairing effect of bone mesenchymal stem cells. Bone marrow mesenchymal stem cells (BMSCs) are applied to treatment of skin wounds. PDGF treatment recruits BSMCs to injured sites and strengthens the effect of BMSCs on skin wound by suppressing activity of MMP-1. SDF-1 treatment increases the treating effect of BMSCs on skin injury through the deposition of collagen I and collagen III. Phenotypes, overview Rattus norvegicus