Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | expression profile of MMPs/TIMP-1 after myocardial infarction, angiotensin II receptor blockade improves MMPs/TIMP-1 balance, overview | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
myocardium | expression profile of MMPs/TIMP-1 after myocardial infarction, angiotensin II receptor blockade improves MMPs/TIMP-1 balance, overview | Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Rattus norvegicus |
MMP-1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | matrix metalloproteinases and the tissue inhibitors of MMPs, TIMPs, play a pivotal role in matrix remodeling following myocardial infarction, the MMPs/TIMP-1 balance is perturbed after myocardial infarction. Oral valsartan, but not PD123319 limits infarct size, normalized MMPs/TIMP-1 balance and restores FN level | Rattus norvegicus |