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Literature summary for 3.4.24.7 extracted from

  • Yang, D.; Ma, S.; Li, D.; Tang, B.; Yang, Y.
    Angiotensin II receptor blockade improves matrix metalloproteinases/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium (2009), Biochem. Biophys. Res. Commun., 388, 606-611.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1 expression profile of MMPs/TIMP-1 after myocardial infarction, angiotensin II receptor blockade improves MMPs/TIMP-1 balance, overview Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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male Wistar rats
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Source Tissue

Source Tissue Comment Organism Textmining
myocardium expression profile of MMPs/TIMP-1 after myocardial infarction, angiotensin II receptor blockade improves MMPs/TIMP-1 balance, overview Rattus norvegicus
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Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
Rattus norvegicus
MMP-1
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function matrix metalloproteinases and the tissue inhibitors of MMPs, TIMPs, play a pivotal role in matrix remodeling following myocardial infarction, the MMPs/TIMP-1 balance is perturbed after myocardial infarction. Oral valsartan, but not PD123319 limits infarct size, normalized MMPs/TIMP-1 balance and restores FN level Rattus norvegicus