Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | dexamethasone induces myocardial matrix degradation by MMP-1 | Rattus norvegicus | |
thyroid hormone | thyroid hormone induces myocardial matrix degradation by MMP-1 activation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tissue inhibitor of matrix metalloproteinase-1 | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | Rattus norvegicus | degradation | ? | - |
? | |
collagen III + H2O | Rattus norvegicus | degradation | ? | - |
? | |
additional information | Rattus norvegicus | myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | the MMP-1 levels are altered in the left ventricle and serum in case of hypertrophy through hyperthyroid conditions with 3,5,3'-triiodo-L-thyroine or dexamethasone application, tissue distribution, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen I + H2O | degradation | Rattus norvegicus | ? | - |
? | |
collagen III + H2O | degradation | Rattus norvegicus | ? | - |
? | |
additional information | myocardial matrix degradation by MMP-1 induced by thyroid hormone through enzyme activation, enzyme regulation involving suppression of tissue inhibitors of matrix metalloproteinases TIMPs and distribution, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-1 | - |
Rattus norvegicus |
MMP-1 | - |
Rattus norvegicus |