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Literature summary for 3.4.24.7 extracted from

  • Fineschi, S.; Reith, W.; Guerne, P.A.; Dayer, J.; Chizzolini, C.
    Proteasome blockade exerts an antifibrotic activity by coordinately down-regulating type I collagen and tissue inhibitor of metalloproteinase-1 and up-regulating metalloproteinase-1 production in human dermal fibroblasts (2006), FASEB J., 20, 562-564.
    View publication on PubMed
Search for more literature for 3.4.24.7

Activating Compound

Activating Compound Comment Organism Structure
additional information proteasome blockade, regardless of the inhibitor used, e.g. proteasome inhibitor I, MG-132, lactacystin, or bortezomib, decreases the production of type I collagen and TIMP-1 and up-regulates that of MMP-1, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Tissue inhibitor of metalloproteinase-1 TIMP-1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen I + H2O Homo sapiens degradation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast dermal, quantitative MMP-1 expression analysis by RT-PCR Homo sapiens
-
skin
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 quantitative MMP-1 expression analysis by RT-PCR Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen I + H2O degradation Homo sapiens ?
-
 ?
collagen I + H2O degradation, calf skin substrate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-1
-
 Homo sapiens
MMP-1
-
 Homo sapiens