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Literature summary for 3.4.24.69 extracted from

  • Matsui, T.; Gu, S.; Lam, K.; Carter, L.; Rummel, A.; Mathews, I.; Jin, R.
    Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex (2014), J. Mol. Biol., 426, 3773-3782.
    View publication on PubMedView publication on EuropePMC
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Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with non-toxic non-hemagglutinin protein, small-angle X-ray scattering Clostridium botulinum

Protein Variants

Protein Variants Comment Organism
E224Q/R363A/Y366F enzymatically inactive Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SNAP-25 + H2O Clostridium botulinum
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum P10845 botulinum neurotoxin subtype A
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O
-
 Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT/A subtype Clostridium botulinum
Botulinum neurotoxin
-
 Clostridium botulinum

General Information

General Information Comment Organism
physiological function non-toxic non-hemagglutinin protein forms the minimally functional progenitor toxin complex with botulinum neurotoxin which protects the enzyme in the gastrointestinal tract at acidic pH values and releases it upon entry into the circulation Clostridium botulinum