Protein Variants | Comment | Organism |
---|---|---|
R230L | inactive | Clostridium botulinum |
Y365N | inactive | Clostridium botulinum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
24-mer C-terminal peptide of LcE1 | the activity of the light chain of botulinum toxin A is significantly reduced to 32% by the peptide with sequence TGRGLVKKIIRFCKNIVSVKGIRK | Clostridium botulinum | |
32-mer C-terminal peptide of LcA | the activity of the light chain of botulinum toxin A is significantly reduced to 15% by the peptide with sequence KNFTGLFEFYKLLCVRGIITSKTKSLDKGYNK | Clostridium botulinum | |
additional information | the C-terminal peptides of LcB-1, LcC1-1, LcD-1, and LcF-1 show no inhibitory effect | Clostridium botulinum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.6 | - |
SNAP-25 | full-length light chain of botulinum toxin A, in 50 mM HEPES, pH 7.4, at 37°C | Clostridium botulinum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP-25 + H2O | - |
Clostridium botulinum | ? | - |
? | |
VAMP + H2O | - |
Clostridium botulinum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BoNT/A | - |
Clostridium botulinum |
Botulinum neurotoxin | - |
Clostridium botulinum |
LCA | light chain of botulinum neurotoxin A | Clostridium botulinum |
LcB | light chain of botulinum neurotoxin B | Clostridium botulinum |
lcc1 | light chain of botulinum neurotoxin C1 | Clostridium botulinum |
LCD | light chain of botulinum neurotoxin D | Clostridium botulinum |
LCE | light chain of botulinum neurotoxin E | Clostridium botulinum |
LCF | light chain of botulinum neurotoxin F | Clostridium botulinum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
38.1 | - |
SNAP-25 | full-length light chain of botulinum toxin A, in 50 mM HEPES, pH 7.4, at 37°C | Clostridium botulinum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00453 | - |
32-mer C-terminal peptide of LcA | full-length light chain of botulinum toxin A, in 50 mM HEPES, pH 7.4, at 37°C | Clostridium botulinum |