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Literature summary for 3.4.24.69 extracted from

  • Niwa, K.; Yoneyama, T.; Ito, H.; Taira, M.; Chikai, T.; Kouguchi, H.; Suzuki, T.; Hasegawa, K.; Miyata, K.; Inui, K.; Ikeda, T.; Watanabe, T.; Ohyama, T.
    Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells (2010), Vet. Microbiol., 141, 312-320.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
N-acetyl neuraminic acid both binding and permeation of toxins are potently inhibited by N-acetyl neuraminic acid in the cell culture mediumor by treatment of the cells with neuraminidase, but neither galactose, lactose nor N-acetyl galactosamine inhibit binding or permeation of toxins Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Clostridium botulinum sialic acid-dependent binding is required for the transcytosis of serotype D botulinum neurotoxin and toxin complex L-TC in rat intestinal epithelial cell line IEC-6, mechanism, overview. HA-33 molecules play an important role in the effective binding of D-4947 L-TC to Caco-2 cells ?
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 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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 strain 4947, BoNT/D
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Purification (Commentary)

Purification (Comment) Organism
BoNT serotype D and enzyme large toxin complex, L-TC, from strain 4947, by ammonium sulfate fractionation, cation exchange chromatography, another step of ammonium sulfate fractionation, and gel filtration Clostridium botulinum

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sialic acid-dependent binding is required for the transcytosis of serotype D botulinum neurotoxin and toxin complex L-TC in rat intestinal epithelial cell line IEC-6, mechanism, overview. HA-33 molecules play an important role in the effective binding of D-4947 L-TC to Caco-2 cells Clostridium botulinum ?
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 ?

Synonyms

Synonyms Comment Organism
BoNT
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 Clostridium botulinum
D-4947 L-TC
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 Clostridium botulinum
serotype D botulinum neurotoxin
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 Clostridium botulinum

General Information

General Information Comment Organism
additional information A large toxin complex, L-TC, produced by Clostridium botulinum is composed of neurotoxin BoNT, non-toxic non-hemagglutinin, and hemagglutinin subcomponents, HA-70, -33 and -17 Clostridium botulinum