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Literature summary for 3.4.24.69 extracted from

  • Amend, B.; Castro-Diaz, D.; Chartier-Kastler, E.; De Ridder, D.; Everaert, K.; Spinelli, M.; van Keerebroeck, P.; Sievert, K.D.
    [Second-line-Therapie der idiopathisch beraktiven Blase. Sakrale Neuromodulation und Botulinumtoxin A] (2010), Urologe, 49, 245-252.
    View publication on PubMed
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Application

Application Comment Organism
medicine clinical evidence on the effectiveness and reliability of minimally invasive and reversible sacral neuromodulation and botulinum tox­in A treatment as well as the current significance of sacral neuromodulation and botulinum toxin A for the second-line treat­ment of adult syndrome of idiopathic overactive blad­der, overview Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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Synonyms

Synonyms Comment Organism
Botulinum neurotoxin
-
 Clostridium botulinum
Botulinumtoxin A
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 Clostridium botulinum

General Information

General Information Comment Organism
physiological function the pharmacologic effect of Botulinum­toxin A includes a reversible blockade of acetylcholine, inhibition of other neurotransmitters, e.g. Substance P and ATP, and the downregulation of axonalexpression of purinergic P2X3- and capsaicin TPRV1-receptors at the nerve endings of the suburothelium, all leading to afferent desensibilization Clostridium botulinum