Localization | Comment | Organism | GeneOntology No. | Textmining |
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Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP-25 + H2O | Clostridium botulinum | i.e. 25-kDa synaptosome-associated protein | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
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Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP-25 + H2O | i.e. 25-kDa synaptosome-associated protein | Clostridium botulinum | ? | - |
? | |
SNAP-25 + H2O | i.e. 25-kDa synaptosome-associated protein. The BoNT/E-truncated C-terminal peptide of SNAP-25 is CDMGNEIDTQNRQIDR | Clostridium botulinum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BoNT/E | - |
Clostridium botulinum |
botulinum neurotoxin E | - |
Clostridium botulinum |
General Information | Comment | Organism |
---|---|---|
physiological function | protective potential of the synaptic blocker BoNT/E, that prevents vesicle fusion via the cleavage of the SNARE, i.e. soluble NSF-attachment receptor, protein SNAP-25, i.e. synaptosomal-associated protein of 25 kDa. Acute neuroprotection by the synaptic blocker botulinum neurotoxin E in a Sprague-Dawley adult female rat model of focal cerebral ischemia. BoNT/E inhibits ET-1-induced glutamate release in the hippocampus | Clostridium botulinum |