Literature summary for 3.4.24.69 extracted from

Thyagarajan, B.; Krivitskaya, N.; Potian, J.G.; Hognason, K.; Garcia, C.C.; McArdle, J.J.
Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin A (2009), J. Pharmacol. Exp. Ther., 331, 361-371.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	capsaicin interacts with TRPV1 receptors, transient receptor potential proteins of the vanilloid subfamily, on motor nerve endings to reduce BoNT/A uptake into Neuro 2a cells via a Ca2+-dependent mechanism, but capsaicin fails to protect against the neuroparalytic effects of BoNT/A. Capsaicin protects muscle functions and electromygraphic activity from the incapacitating effects of BoNT/A. Capsazepine pretreatment antagonizes the protective effect of capsaicin on acetylcholine release at high frequencies	Clostridium botulinum

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	serotype BoNT/A	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	BoNT/A activity in muscle, twitch tension, overview	Clostridium botulinum

Subunits

Subunits	Comment	Organism
More	BoNT/A is composed of a heavy (HC) and light (LC) chain linked by a disulfide bond	Clostridium botulinum

Synonyms

Synonyms	Comment	Organism
BoNT/A	-	Clostridium botulinum
botulinum neurotoxin a	-	Clostridium botulinum

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Release 2023.1 (January 2023)