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Literature summary for 3.4.24.69 extracted from
- Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy (2008), Exp. Neurol., 210, 388-401.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium botulinum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
status epilepticus induced in Mus musculus C57BL/6N. Mouse treatment with BoNT/E delays the onset of chronic epilepsy but does not inhibit the occurrence of spontaneous seizures. BoNT/E reduces loss of CA1 pyramidal neurons and dispersion of dentate granule cells. BoNT/E supresses the downregulation of reelin mRNA expression along the hippocampal fissure. | Clostridium botulinum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BoNT/E | - |
Clostridium botulinum |
| botulinum neurotoxin E | - |
Clostridium botulinum |
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