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Literature summary for 3.4.24.69 extracted from

  • Sinha, J.; Inan, M.; Fanders, S.; Taoka, S.; Gouthro, M.; Swanson, T.; Barent, R.; Barthuli, A.; Loveless, B.M.; Smith, L.A.; Smith, T.; Henderson, I.; Ross, J.; Meagher, M.M.
    Cell bank characterization and fermentation optimization for production of recombinant heavy chain C-terminal fragment of botulinum neurotoxin serotype E (rBoNTE(H(c)): antigen E) by Pichia pastoris (2007), J. Biotechnol., 127, 462-474.
    View publication on PubMed
Search for more literature for 3.4.24.69

Application

Application Comment Organism
medicine process development for production of a candidate vaccine antigen by recombinant expression of the C-terminal heavy chain fragment of botulinum neurotoxin serotype E Pichia pastoris strain GS115 Clostridium botulinum

Cloned(Commentary)

Cloned (Comment) Organism
cell bank construction, expression of the C-terminal heavy chain fragment of botulinum neurotoxin serotype E in Pichia pastoris strain GS115, method development and evaluation using the pHILD4 Escherichia coli-Pichia pastoris shuttle plasmid, fermentation up-scaling, modeling, overview Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SNAP25 + H2O Clostridium botulinum i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane ?
-
 ?
SNAP25 + H2O Clostridium botulinum NCTC 11219 i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-
Clostridium botulinum NCTC 11219
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP25 + H2O i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane Clostridium botulinum ?
-
 ?
SNAP25 + H2O i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane Clostridium botulinum ?
-
 ?
SNAP25 + H2O i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane Clostridium botulinum NCTC 11219 ?
-
 ?
SNAP25 + H2O i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane Clostridium botulinum NCTC 11219 ?
-
 ?

Synonyms

Synonyms Comment Organism
antigen E
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 Clostridium botulinum
BoNTE
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 Clostridium botulinum
botulinum neurotoxin serotype E
-
 Clostridium botulinum
HCE
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 Clostridium botulinum