Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-phenyl-2-acylguanidyl thiophenes | compounds containing a 2-acylthiophene moiety as a zinc-binding functionality, combined with acylguanidyl groups as an arginine side chain mimetic, structure-activity relationship of 5-phenyl-2-acylguanidyl thiophene activators of BoNT LC/A under standard screening conditions, overview | Clostridium botulinum | |
5-[3-(butylsulfanyl)phenyl]-N-carbamimidoylthiophene-2-carboxamide | 4fold activation of BoNT LC/A | Clostridium botulinum | |
5-[4-(butylsulfanyl)phenyl]-N-carbamimidoylthiophene-2-carboxamide | 7fold activation, BoNT LC/A activation profile, overview | Clostridium botulinum | |
additional information | identification of a small molecule scaffold based on 2-acyl guanidyl-5-phenyl thiophenes that strongly activates BoNT LC/A catalytic activity through an apparent reduction in KM activator screening, overview | Clostridium botulinum | |
N-carbamimidoyl-5-[3-(ethylsulfanyl)phenyl]thiophene-2-carboxamide | 4fold activation of BoNT LC/A | Clostridium botulinum | |
N-carbamimidoyl-5-[3-(methylsulfanyl)phenyl]thiophene-2-carboxamide | 3fold activation of BoNT LC/A | Clostridium botulinum | |
N-carbamimidoyl-5-[4-(ethylsulfanyl)phenyl]thiophene-2-carboxamide | 3.5fold activation of BoNT LC/A | Clostridium botulinum | |
N-carbamimidoyl-5-[4-(propylsulfanyl)phenyl]thiophene-2-carboxamide | 7fold activation of BoNT LC/A | Clostridium botulinum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP-25 + H2O | Clostridium botulinum | i.e. synaptosomal associated protein of 25 kDa | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP-25 + H2O | i.e. synaptosomal associated protein of 25 kDa | Clostridium botulinum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BoNT LC/A | - |
Clostridium botulinum |
Botulinum neurotoxin | - |
Clostridium botulinum |
botulinum neurotoxin serotype A light chain | - |
Clostridium botulinum |