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Literature summary for 3.4.24.69 extracted from

  • Burnett, J.C.; Schmidt, J.J.; Stafford, R.G.; Panchal, R.G.; Nguyen, T.L.; Hermone, A.R.; Vennerstrom, J.L.; McGrath, C.F.; Lane, D.J.; Sausville, E.A.; Zaharevitz, D.W.; Gussio, R.; Bavari, S.
    Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity (2003), Biochem. Biophys. Res. Commun., 310, 84-93.
    View publication on PubMed

Application

Application Comment Organism
medicine most lethal biological substance have been weaponized in highly toxic aerosol form to pose a significant dual threat to both civilian and military populations, there is an urgent need for therapeutic countermeasures against BoNTs Clostridium botulinum

Inhibitors

Inhibitors Comment Organism Structure
amodiaquine antimalarial drug, 30% inhibition Clostridium botulinum
bisquinoline Q2-15 60% inhibition Clostridium botulinum
bisquinoline Q2-61 50% inhibition Clostridium botulinum
Chloroquine antimalarial drug, 20% inhibition Clostridium botulinum
NSC 119889 56% inhibition Clostridium botulinum
NSC 130796 48% inhibition Clostridium botulinum
NSC 357756 57% inhibition Clostridium botulinum
NSC 402959 40% inhibition Clostridium botulinum
NSC 625324 (silver sulfadiazine) 100% inhibition Clostridium botulinum
NSC 661755 (michellamine B) 62% inhibition Clostridium botulinum
NSC 86372 51% inhibition Clostridium botulinum
Quinacrine antimalarial drug, 30% inhibition Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
SNARE-protein + H2O Clostridium botulinum soluble NSF-attachment protein receptor ?
-
?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O
-
Clostridium botulinum ?
-
?
SNARE-protein + H2O soluble NSF-attachment protein receptor Clostridium botulinum ?
-
?
synaptobrevin + H2O
-
Clostridium botulinum ?
-
?
Syntaxin + H2O
-
Clostridium botulinum ?
-
?

Synonyms

Synonyms Comment Organism
BoNT
-
Clostridium botulinum
BoNT/A LC
-
Clostridium botulinum
neurotoxin A
-
Clostridium botulinum