Application | Comment | Organism |
---|---|---|
medicine | very powerful neurotoxin, agent responsible for all clinical symptoms of tetanus | Clostridium tetani |
Cloned (Comment) | Organism |
---|---|
tetanus neurotoxin light chain, expressed in Escherichia coli | Clostridium tetani |
Crystallization (Comment) | Organism |
---|---|
crystals obtained with the hanging drop method | Clostridium tetani |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc endopeptidase | Clostridium tetani |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
150000 | - |
activated by proteolytic cleavage with formation of a 50 kDa L-chain and a 100 kDa H-chain | Clostridium tetani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Clostridium tetani | most powerful known natural toxin | ? | - |
? | |
additional information | Clostridium tetani Y-IV-3 | most powerful known natural toxin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium tetani | - |
- |
- |
Clostridium tetani Y-IV-3 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
tetanus neurotoxin light chain | Clostridium tetani |
Storage Stability | Organism |
---|---|
4°C, both native and recombinant TeNT L-chains show significant decreases after 3-4 days of storage | Clostridium tetani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | most powerful known natural toxin | Clostridium tetani | ? | - |
? | |
additional information | most powerful known natural toxin | Clostridium tetani Y-IV-3 | ? | - |
? | |
vesicle-associated membrane protein VAMP + H2O | L-chain highly specific for the substrate | Clostridium tetani | ? | - |
? | |
vesicle-associated membrane protein VAMP + H2O | L-chain highly specific for the substrate | Clostridium tetani Y-IV-3 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TeNT | - |
Clostridium tetani |
Tetanus neurotoxin | - |
Clostridium tetani |