Application | Comment | Organism |
---|---|---|
medicine | causative agent of the disease tetanus | Clostridium tetani |
Crystallization (Comment) | Organism |
---|---|
- |
Clostridium tetani |
Protein Variants | Comment | Organism |
---|---|---|
D1222L | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
G1215F | sialic acid binding site mutant, mutation generated by PCR | Clostridium tetani |
G1300F | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
H1271A | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
H1271W | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
H1293A | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
N1219I | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
N1220I | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
R1226F | sialic acid binding site mutant, mutation generated by PCR | Clostridium tetani |
R1226L | sialic acid binding site mutant, mutation generated by PCR | Clostridium tetani |
S1287A | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
W1289G | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
W1289L | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
Y1290A | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
Y1290F | lactose-binding site mutant, mutation generated by PCR | Clostridium tetani |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-dependent endopeptidase | Clostridium tetani |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
150000 | - |
single-chain protein, cleaved by proteases into a 100 kDa heavy chain HC and a 50 kDa light chain LC, SELDI-TOF MS | Clostridium tetani |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Clostridium tetani | most powerful known natural toxin, 2 carbohdrate binding sites in the Hcc-domain of tetanus neurotoxin are required for toxicity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium tetani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
wild-type and mutated recombinant Hc-fragments | Clostridium tetani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | most powerful known natural toxin, 2 carbohdrate binding sites in the Hcc-domain of tetanus neurotoxin are required for toxicity | Clostridium tetani | ? | - |
? | |
rat synaptobrevin 2 + H2O | catalytic activity of all mutants | Clostridium tetani | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TeNT | - |
Clostridium tetani |
Tetanus neurotoxin | - |
Clostridium tetani |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | 60 | Tm-value 58.4°C | Clostridium tetani |