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Literature summary for 3.4.24.65 extracted from

  • Cheng, P.; Jiang, F.H.; Zhao, L.M.; Dai, Q.; Yang, W.Y.; Zhu, L.M.; Wang, B.J.; Xu, C.; Bao, Y.J.; Zhang, Y.J.
    Human macrophage metalloelastase correlates with angiogenesis and prognosis of gastric carcinoma (2010), Digest. Dis. Sci., 55, 3138-3146.
    View publication on PubMed
Search for more literature for 3.4.24.65

Application

Application Comment Organism
diagnostics overexpression of HME is strongly correlated with the reduced angiogenesis and vascular invasion of gastric carcinoma, and may serve as a useful predictive indicator in patients with this disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
 x * 54000, pro-MMP-12, x * 29000, mature active MMP-12 Homo sapiens
54000
-
 x * 54000, pro-MMP-12, x * 29000, mature active MMP-12 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Elastin + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens HME has the ability to convert plasminogen into angiostatin, an essential and potent inhibitor of endothelial cell proliferation and tumor angiogenesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric adenocarcinoma cell HME protein levels are 4.50-7.15fold increased in gastric carcinoma samples compared with the non-cancerous controls Homo sapiens
-
macrophage
-
 Homo sapiens
-
stomach HME is expressed in chronic gastritis with atypical hyperplasia and normal gastric epithelium mucosa. HME protein levels are 4.50-7.15fold increased in gastric carcinoma samples compared with the non-cancerous controls Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
additional information HME has the ability to convert plasminogen into angiostatin, an essential and potent inhibitor of endothelial cell proliferation and tumor angiogenesis Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, pro-MMP-12, x * 29000, mature active MMP-12 Homo sapiens

Synonyms

Synonyms Comment Organism
HME
-
 Homo sapiens
Human macrophage metalloelastase
-
 Homo sapiens
matrix metalloproteinase 12
-
 Homo sapiens
MMP-12
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function HME is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. Overexpression of HME is strongly correlated with the reduced angiogenesis and vascular invasion of gastric carcinoma Homo sapiens