Application | Comment | Organism |
---|---|---|
analysis | the enzyme can be utilized for pharmacological evaluation of anti-inflammatory mechanisms of action | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dexamethasone | in vivo inhibition of the human enzyme in mice leading to inhibited cytokine release and neutrophil influx, overview | Homo sapiens | |
marimastat | in vivo inhibition of the human enzyme in mice leading to inhibited macrophage recruitment, neutrophil influx, and cytokine release, overview | Homo sapiens | |
rolipram | in vivo inhibition of the human enzyme in mice leading to inhibited neutrophil influx, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme induces inflammation in murine airways after direct instillation eliciting the inflammatory response by neutrophil influx, cytokine release, and gelatinase activation, and delayed response by macrophage recruitment, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme induces inflammation in murine airways after direct instillation eliciting the inflammatory response by neutrophil influx, cytokine release, and gelatinase activation, and delayed response by macrophage recruitment, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Metalloelastase | - |
Homo sapiens |
MMP-12 | - |
Homo sapiens |