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Literature summary for 3.4.24.65 extracted from
- Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma (2007), Biol. Pharm. Bull., 30, 318-323.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | MMP-12 is upregulated after the induction of asthmatic reaction | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | MMP-12 might be a target for the therapy against allergic bronchial asthma | Rattus norvegicus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
| 54000 | - |
x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the enzyme is involved in the development of chronic obstructive pulmonary disease and airway inflammation and is associated with allergic bronchial asthma, phenotype, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelium | airway epithelia | Rattus norvegicus | - |
| macrophage | alveolar macrophages | Rattus norvegicus | - |
| additional information | immunohistochemical expression analysis | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
quantitative enzyme expression analysis by RT-PCR, overview | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-casein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| additional information | the enzyme is involved in the development of chronic obstructive pulmonary disease and airway inflammation and is associated with allergic bronchial asthma, phenotype, overview | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 54000, inactive proenzyme, x * 45000, intermediate enzyme | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Matrix metalloproteinase-12 | - |
Rattus norvegicus |
| MMP-12 | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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