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Literature summary for 3.4.24.65 extracted from

  • Nar, H.; Werle, K.; Bauer, M.M.; Dollinger, H.; Jung, B.
    Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor (2001), J. Mol. Biol., 312, 743-751.
    View publication on PubMed
Search for more literature for 3.4.24.65

Cloned(Commentary)

Cloned (Comment) Organism
molecular cloning of the proteinase domain of MMP12 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
hexagonal shaped crystals, crystal structure in complex with hydroxamic acid inhibitor, orthorhombic space group I222, unit cells dimensions a : 67.4 A, b : 87.2, c : 169.2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CGS27023A
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ catalytic zinc ion Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 MMp-12 active enzyme Homo sapiens
54000
-
 MMp-12 proenzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens important role in inflammatory processes contributing to tissue remodelling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Elastin + H2O
-
 Homo sapiens ?
-
 ?
additional information important role in inflammatory processes contributing to tissue remodelling Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
human macrophage elastase
-
 Homo sapiens
MMP-12
-
 Homo sapiens