Protein Variants | Comment | Organism |
---|---|---|
additional information | generation and genotyping of meprin beta-knockout mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | markedly prevents urinary excretion of the cleaved nidogen-1 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
brush border membrane | - |
Mus musculus | 31526 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nidogen-1 + H2O | Mus musculus | - |
? | - |
? | |
nidogen-1 + H2O | Mus musculus C57BL/6N | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q61847 | - |
- |
Mus musculus C57BL/6N | Q61847 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
additional information | During acute kidney injury (AKI) induced by cisplatin or ischemia-reperfusion, membrane-bound meprins are shed and their localization is altered from the apical membranes toward the basolateral surface of the proximal tubules | Mus musculus | - |
renal proximal tubule | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nidogen-1 + H2O | - |
Mus musculus | ? | - |
? | |
nidogen-1 + H2O | - |
Mus musculus C57BL/6N | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | meprin beta-deficient mice, but not meprin alpha-deficient mice, subjected to cisplatin nephrotoxicity, significantly suppress excretion of cleaved nidogen-1 | Mus musculus |
metabolism | during acute kidney injury induced by cisplatin or ischemia-reperfusion, membrane-bound meprins are shed and their localization is altered from the apical membranes toward the basolateral surface of the proximal tubules. Meprins are capable of cleaving basement membrane proteins in vitro and in vivo | Mus musculus |
physiological function | basement membrane protein nidogen-1 is a target of meprin beta in cisplatin nephrotoxicity | Mus musculus |