Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | binding sites and binding structure of hydroxamic acid derivative inhibitors, molecular dynamics simulation study, overview | Homo sapiens | |
Pro-Leu-Gly-hydroxamate | binding structure in S subsites, overview. A decrease in solvent accessibility values at specific residues upon inhibitor binding occurs. The S subsite of the enzyme interacts with residues at P site of the inhibitor | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | meprin beta is a metalloprotease of the astacin family characterized by a conserved zinc-binding motif (HExxHxxGFxHExxRxDR) | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16820 | - |
- |
General Information | Comment | Organism |
---|---|---|
evolution | meprin beta is a metalloprotease of the astacin family characterized by a conserved zinc-binding motif (HExxHxxGFxHExxRxDR). Human meprin-alpha, EC 3.4.24.18, and -beta protease subunits are 55% identical at the amino acid level, while the substrate and peptide bond specificities vary markedly | Homo sapiens |
additional information | homology modeling of the protease domain of meprin beta on the astacin crystal structure and molecular dynamics simulation study, overview | Homo sapiens |