Literature summary for 3.4.24.63 extracted from

Li, Y.; Fan, Y.; Tang, J.; Li, J.; Yu, C.
Meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages (2014), Int. Immunopharmacol., 18, 77-84.

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Application

Application	Comment	Organism
pharmacology	meprin-beta is strong candidate for a proinflammatory target	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q16820	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
macrophage	from primary human peripheral blood	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
meprin-beta	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	meprin-beta regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages. Meprin-beta increases the production of pro-inflammatory cytokines, including interleukin-1beta, interleukin-18 and interleukin-6 in macrophages, but shows no effects on the level of ligands of epidermal growth factor receptor and its activation. Activation of NF-kappaB by meprin-beta is mediated by inhibiting ADAM10-downstream extracellular signal regulated kinase (ERK1/2) pathway, molecular mechanism, overview. Meprin-beta significantly induces the phosphorylation of ERK1/2 and its upstream MEK1/2	Homo sapiens

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Release 2023.1 (January 2023)