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Literature summary for 3.4.24.63 extracted from

  • Bertenshaw, G.P.; Villa, J.P.; Hengst, J.A.; Bond, J.S.
    Probing the active sites and mechanisms of rat metalloproteases meprin A and B (2002), Biol. Chem., 383, 1175-1183.
    View publication on PubMed
Search for more literature for 3.4.24.63

Activating Compound

Activating Compound Comment Organism Structure
Trypsin
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
recombinant His-tagged enzyme, cDNA transfected into human embryonic kidney 293 cells Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00104
-
 bradykinin pH 7.5, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Rattus norvegicus 9986
-
extracellular
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc-dependent endopeptidase Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 rat
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-MGWMDEIDK(2,4-dinitrophenyl)SG + H2O
-
 Rattus norvegicus 2-aminobenzoyl-MGWM + DEIDK(2,4-dinitrophenyl)SG
-
 ?
bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?
Cholecystokinin + H2O
-
 Rattus norvegicus ?
-
 ?
orcokinin + H2O
-
 Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
oligomer homooligomer Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
11
-
 bradykinin pH 7.5, 37°C Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
4.5 10
-
 Rattus norvegicus