Literature summary for 3.4.24.62 extracted from

Clamagirand, C.; Camier, M.; Fahy, C.; Clavreul, C.; Creminon, C.; Cohen, P.
C-terminally extended ocytocin and pro-ocytocin: neurophysin peptide converting enzyme in bovine corpus luteum [published erratum appears in Biochem Biophys Res Commun 1987 May 14;144(3):1349] (1987), Biochem. Biophys. Res. Commun., 143, 789-796.

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Inhibitors

Inhibitors	Comment	Organism	Structure
EDTA	strong, 2.5 mM	Bos taurus
EGTA	strong, 2.5 mM	Bos taurus
additional information	no inhibition by PMSF, pepstatin	Bos taurus
p-chloromercuriphenylsulfonic acid	2.5 mM	Bos taurus
PCMB	2.5 mM	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
secretory granule	-	Bos taurus	30141	-

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	cow	-
Bos taurus	-	superovulated and fecondated cow	-

Purification (Commentary)

Purification (Comment)	Organism
-	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
corpus luteum	day 7-8 after heat period	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	No substrates are Nle11 or Nle12	Bos taurus	?	-	?
additional information	No substrates are pro-oxytocin/neurophysin peptides (i.e. pro-OT/Np(1-20)) with D-Arg12	Bos taurus	?	-	?
Pro-oxytocin/neurophysin(1-20) + H2O	strictly selective for basic amino acid doublet Lys11-Arg12, cleavage site: Arg12-Ala13	Bos taurus	Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)	i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III)	?
Pro-oxytocin/neurophysin(1-20) + H2O	i.e. model substrate peptide I	Bos taurus	Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)	i.e. peptide II (i.e. oxytocinGly10Lys11Arg12 and peptide III)	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
additional information	-	pI: 4.5	Bos taurus
7	-	around, peptide I as substrate	Bos taurus

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Release 2023.1 (January 2023)