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Literature summary for 3.4.24.61 extracted from

  • Bernstein, H.; Stricker, R.; Dobrowolny, H.; Steiner, J.; Bogerts, B.; Trübner, K.; Reiser, G.
    Nardilysin in human brain diseases: both friend and foe (2013), Amino Acids, 45, 269-278.
    View publication on PubMed
Search for more literature for 3.4.24.61

Application

Application Comment Organism
medicine the enzyme plays a role in the pathophysiology of schizophrenia Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-neoendorphin + H2O Homo sapiens
-
 ?
-
 ?
dynorphin A + H2O Homo sapiens
-
 ?
-
 ?
Glucagon + H2O Homo sapiens
-
 ?
-
 ?
malate dehydrogenase + H2O Homo sapiens
-
 ?
-
 ?
somatostatin-28 + H2O Homo sapiens
-
 ?
-
 ?
tumor necrosis factor-alpha + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43847
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-neoendorphin + H2O
-
 Homo sapiens ?
-
 ?
dynorphin A + H2O
-
 Homo sapiens ?
-
 ?
Glucagon + H2O
-
 Homo sapiens ?
-
 ?
malate dehydrogenase + H2O
-
 Homo sapiens ?
-
 ?
somatostatin-28 + H2O
-
 Homo sapiens ?
-
 ?
tumor necrosis factor-alpha + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
 Homo sapiens
NRDc
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens there is strongly decreased neuronal enzyme expression in Down syndrome. The enzyme is down-regulated (about 1.21fold) in brains of individuals with bipolar disorder down
Homo sapiens the enzyme is highly expressed in neuroblastoma cells up

General Information

General Information Comment Organism
physiological function the interaction between the enzyme and centaurin-1alpha contribute to brain structural damage observed in Alzheimer's disease Homo sapiens