Application | Comment | Organism |
---|---|---|
medicine | the enzyme plays a role in the pathophysiology of schizophrenia | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-neoendorphin + H2O | Homo sapiens | - |
? | - |
? | |
dynorphin A + H2O | Homo sapiens | - |
? | - |
? | |
Glucagon + H2O | Homo sapiens | - |
? | - |
? | |
malate dehydrogenase + H2O | Homo sapiens | - |
? | - |
? | |
somatostatin-28 + H2O | Homo sapiens | - |
? | - |
? | |
tumor necrosis factor-alpha + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43847 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-neoendorphin + H2O | - |
Homo sapiens | ? | - |
? | |
dynorphin A + H2O | - |
Homo sapiens | ? | - |
? | |
Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
malate dehydrogenase + H2O | - |
Homo sapiens | ? | - |
? | |
somatostatin-28 + H2O | - |
Homo sapiens | ? | - |
? | |
tumor necrosis factor-alpha + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-Arginine dibasic convertase | - |
Homo sapiens |
NRDc | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | there is strongly decreased neuronal enzyme expression in Down syndrome. The enzyme is down-regulated (about 1.21fold) in brains of individuals with bipolar disorder | down |
Homo sapiens | the enzyme is highly expressed in neuroblastoma cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the interaction between the enzyme and centaurin-1alpha contribute to brain structural damage observed in Alzheimer's disease | Homo sapiens |