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Literature summary for 3.4.24.61 extracted from

  • Li, J.; Chu, M.; Wang, S.; Chan, D.; Qi, S.; Wu, M.; Zhou, Z.; Li, J.; Nishi, E.; Qin, J.; Wong, J.
    Identification and Characteriation of Nardilysin as a Novel Dimethyl H3K4 Binding Protein Involved in Transcriptional Regulation (2012), J. Biol. Chem., 287, 10089-10098.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.61

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
DELTA1-148 mutant does not bind the H3K4me2 peptide Homo sapiens
DELTA1-260 mutant binds the H3K4me2 peptide Homo sapiens
DELTA1-445 mutant binds the H3K4me2 peptide Homo sapiens
DELTA1-621 mutant binds the H3K4me2 peptide Homo sapiens
DELTA149-621 mutant does not bind the H3K4me2 peptide Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm although NRDc can also be detected in the cytoplasm, it is enriched in the nucleus in both HeLa and NIH3T3 cells Homo sapiens 5737
-
nucleus although NRDc can also be detected in the cytoplasm, it is enriched in the nucleus in both HeLa and NIH3T3 cells Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens NRDc interacts with the NCoR/SMRT corepressor complex ?
-
 ?
additional information Homo sapiens NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43847
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NRDc interacts with the NCoR/SMRT corepressor complex Homo sapiens ?
-
 ?
additional information NRDc is identifiend as a H3K4me2-binding protein. The H3K4me2-binding activity resides in the N-terminal region of NRDc Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
nardilysin
-
 Homo sapiens
NRDc
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function NRDc is physically associated with and recruits the NCoR complex to some of the repressed genes and this association correlates with binding of H3K4me2 Homo sapiens