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Literature summary for 3.4.24.61 extracted from

  • Ohno, M.; Hiraoka, Y.; Matsuoka, T.; Tomimoto, H.; Takao, K.; Miyakawa, T.; Oshima, N.; Kiyonari, H.; Kimura, T.; Kita, T.; Nishi, E.
    Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system (2009), Nat. Neurosci., 12, 1506-1513.
    View publication on PubMed
Search for more literature for 3.4.24.61

Protein Variants

Protein Variants Comment Organism
additional information nardilysin null mice have smaller brains and a thin cerebral cortex, in which are less myelinated fibers with thinner myelin sheaths and smaller axon diameters, compared to wild-type mice. The mutants show hypomyelination in the peripheral nervous system, phenotype, overview. Neuron-specific overexpression of nardilysin induces hypermyelination Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus nardilysin enhances ectodomain shedding of neuregulin1, NRG1, a master regulator of myelination in the peripheral nervous system ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
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 Mus musculus
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peripheral nervous system
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 Mus musculus
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sciatic nerve
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nardilysin enhances ectodomain shedding of neuregulin1, NRG1, a master regulator of myelination in the peripheral nervous system Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
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 Mus musculus
Nrd1
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 Mus musculus
NRDc
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 Mus musculus

General Information

General Information Comment Organism
physiological function nardilysin is essential for regulation of axonal maturation and myelination in the central and peripheral nervous system. Nardilysin is a metalloendopeptidase enhancer of protein ectodomain shedding, is a critical regulator of these processes for establishing an efficient neuronal signaling network. The level of neuronal enzyme regulates myelin thickness Mus musculus