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Literature summary for 3.4.24.61 extracted from

  • Chow, K.M.; Oakley, O.; Goodman, J.; Ma, Z.; Juliano, M.A.; Juliano, L.; Hersh, L.B.
    Nardilysin cleaves peptides at monobasic sites (2003), Biochemistry, 42, 2239-2244.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expressed in Sf9 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
2-aminobenzoyl-GGFIRRVGQ-EDDnp alternate substrate inhibitor Mus musculus
beta-endorphin substrate inhibitor Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
Somatostatin-14 pH 7.0, 37°C Mus musculus
0.00054
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, R-K Mus musculus
0.00117
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, KK Mus musculus
0.0014
-
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine pH 7.0, 37°C Mus musculus
0.0014
-
betaendorphin pH 7.0, 37°C Mus musculus
0.0017
-
calcitonin pH 7.0, 37°C Mus musculus
0.0019
-
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus
0.002
-
dynorphin B13 pH 7.0, 37°C Mus musculus
0.0035
-
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus
0.0041
-
2-aminobenzoyl-MISLMKRPPGFSPFRSSRINH2 pH 7.0, 37°C Mus musculus
0.0077
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, F-K Mus musculus
0.008
-
Somatostatin-14 pH 7.0, 37°C Mus musculus
0.0084
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, WK Mus musculus
0.0135
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, MK Mus musculus
0.0171
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, FR Mus musculus
0.0266
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, YK Mus musculus
0.0466
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, L-K Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ metalloprotease, possessing an inverted active site zinc binding motif Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
130000
-
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus physiological substrates of nardilysin have yet to be identified ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
mouse
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme expressed in Sf9 cells Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-GFSPFRSSRQ-ED(2,4-dinitrophenyl) + H2O
-
Mus musculus ?
-
?
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O
-
Mus musculus ?
-
?
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O kallidin model peptide, nardilysin does not release desArg10 kallidin from the physiological precursor low molecular weight kiniogen Mus musculus desArg10 kallidin (KRPPGFSPF) + ?
-
?
2-aminobenzoyl-MISLMKRPQ-ED(2,4-dinitrophenyl) + H2O
-
Mus musculus ?
-
?
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) + H2O fluorogenic substrate based on beta-endorphin, nardilysin hydrolyzes peptides when X1-X2 are F-K, F-R, W-K, M-K,Y-K, or L-K, K-F is not hydrolyzed Mus musculus ?
-
?
beta-endorphin + H2O
-
Mus musculus Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe + Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gln + ?
-
?
calcitonin + H2O
-
Mus musculus ?
-
?
dynorphin B13 + H2O
-
Mus musculus ?
-
?
additional information physiological substrates of nardilysin have yet to be identified Mus musculus ?
-
?
Somatostatin-14 + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
N-Arginine dibasic convertase
-
Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 pH 7.0, 37°C Mus musculus
0.031 0.51 2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus
0.04 1.97 2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus
0.216
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, LK Mus musculus
0.455
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, WK and MK Mus musculus
0.498
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, KK Mus musculus
0.628
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, FK Mus musculus
0.693
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, RK Mus musculus
0.78
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, YK Mus musculus
0.783
-
Somatostatin-14 pH 7.0, 37°C Mus musculus
0.95
-
Somatostatin-14 pH 7.0, 37°C, reduced somatostatin Mus musculus
1.81
-
calcitonin pH 7.0, 37°C Mus musculus
2.94
-
calcitonin pH 7.0, 37°C Mus musculus
3.3
-
beta-endorphin pH 7.0, 37°C Mus musculus
3.3
-
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine pH 7.0, 37°C Mus musculus
5.03
-
beta-endorphin pH 7.0, 37°C Mus musculus
5.03
-
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine pH 7.0, 37°C Mus musculus
6.08
-
Somatostatin-14 pH 7.0, 37°C Mus musculus
6.08
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, FK Mus musculus
6.08
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, FR Mus musculus
6.08
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, RK Mus musculus
6.08
-
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) pH 7.0, 37°C, YK Mus musculus
7.68
-
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus
9.48
-
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) pH 7.0, 37°C Mus musculus