Cloned (Comment) | Organism |
---|---|
recombinant enzyme expressed in Sf9 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-aminobenzoyl-GGFIRRVGQ-EDDnp | alternate substrate inhibitor | Mus musculus | |
beta-endorphin | substrate inhibitor | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
Somatostatin-14 | pH 7.0, 37°C | Mus musculus | |
0.00054 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, R-K | Mus musculus | |
0.00117 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, KK | Mus musculus | |
0.0014 | - |
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine | pH 7.0, 37°C | Mus musculus | |
0.0014 | - |
betaendorphin | pH 7.0, 37°C | Mus musculus | |
0.0017 | - |
calcitonin | pH 7.0, 37°C | Mus musculus | |
0.0019 | - |
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus | |
0.002 | - |
dynorphin B13 | pH 7.0, 37°C | Mus musculus | |
0.0035 | - |
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus | |
0.0041 | - |
2-aminobenzoyl-MISLMKRPPGFSPFRSSRINH2 | pH 7.0, 37°C | Mus musculus | |
0.0077 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, F-K | Mus musculus | |
0.008 | - |
Somatostatin-14 | pH 7.0, 37°C | Mus musculus | |
0.0084 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, WK | Mus musculus | |
0.0135 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, MK | Mus musculus | |
0.0171 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, FR | Mus musculus | |
0.0266 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, YK | Mus musculus | |
0.0466 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, L-K | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | metalloprotease, possessing an inverted active site zinc binding motif | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
130000 | - |
- |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | physiological substrates of nardilysin have yet to be identified | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme expressed in Sf9 cells | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-aminobenzoyl-GFSPFRSSRQ-ED(2,4-dinitrophenyl) + H2O | - |
Mus musculus | ? | - |
? | |
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine + H2O | - |
Mus musculus | ? | - |
? | |
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 + H2O | kallidin model peptide, nardilysin does not release desArg10 kallidin from the physiological precursor low molecular weight kiniogen | Mus musculus | desArg10 kallidin (KRPPGFSPF) + ? | - |
? | |
2-aminobenzoyl-MISLMKRPQ-ED(2,4-dinitrophenyl) + H2O | - |
Mus musculus | ? | - |
? | |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) + H2O | fluorogenic substrate based on beta-endorphin, nardilysin hydrolyzes peptides when X1-X2 are F-K, F-R, W-K, M-K,Y-K, or L-K, K-F is not hydrolyzed | Mus musculus | ? | - |
? | |
beta-endorphin + H2O | - |
Mus musculus | Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe + Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Gln + ? | - |
? | |
calcitonin + H2O | - |
Mus musculus | ? | - |
? | |
dynorphin B13 + H2O | - |
Mus musculus | ? | - |
? | |
additional information | physiological substrates of nardilysin have yet to be identified | Mus musculus | ? | - |
? | |
Somatostatin-14 + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-Arginine dibasic convertase | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
2-aminobenzoyl-MISLMKRPPGFSPFRSSRI-NH2 | pH 7.0, 37°C | Mus musculus | |
0.031 | 0.51 | 2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus | |
0.04 | 1.97 | 2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus | |
0.216 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, LK | Mus musculus | |
0.455 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, WK and MK | Mus musculus | |
0.498 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, KK | Mus musculus | |
0.628 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, FK | Mus musculus | |
0.693 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, RK | Mus musculus | |
0.78 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, YK | Mus musculus | |
0.783 | - |
Somatostatin-14 | pH 7.0, 37°C | Mus musculus | |
0.95 | - |
Somatostatin-14 | pH 7.0, 37°C, reduced somatostatin | Mus musculus | |
1.81 | - |
calcitonin | pH 7.0, 37°C | Mus musculus | |
2.94 | - |
calcitonin | pH 7.0, 37°C | Mus musculus | |
3.3 | - |
beta-endorphin | pH 7.0, 37°C | Mus musculus | |
3.3 | - |
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine | pH 7.0, 37°C | Mus musculus | |
5.03 | - |
beta-endorphin | pH 7.0, 37°C | Mus musculus | |
5.03 | - |
2-aminobenzoyl-GGFIRRVGQ-N-(2,4-dinitrophenyl)ethylenediamine | pH 7.0, 37°C | Mus musculus | |
6.08 | - |
Somatostatin-14 | pH 7.0, 37°C | Mus musculus | |
6.08 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, FK | Mus musculus | |
6.08 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, FR | Mus musculus | |
6.08 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, RK | Mus musculus | |
6.08 | - |
2-aminobenzoyl-TPLVTLX1X2NAIIKQED(2,4-dinitrophenyl) | pH 7.0, 37°C, YK | Mus musculus | |
7.68 | - |
2-aminobenzoyl-GFSPFRSSRQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus | |
9.48 | - |
2-aminobenzoyl-MISLMKRPQED(2,4-dinitrophenyl) | pH 7.0, 37°C | Mus musculus |