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Literature summary for 3.4.24.59 extracted from

  • Isaya, G.
    Mitochondrial intermediate peptidase (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 366-369.
No PubMed abstract available

Application

Application Comment Organism
additional information MIP stimulates iron uptake by mitochondria Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment) Organism
cloned into vector pG-3 Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae Homo sapiens
expressed in Saccharomyces cerevisiae Rattus norvegicus
expressed in Saccharomyces cerevisiae Schizophyllum commune

Protein Variants

Protein Variants Comment Organism
additional information disruption of the mouse MIP gene results in early embryonic lethality Mus musculus
additional information when MIP is genetically inactivated, the protein is no longer processed to the mature form, resulting in a complex respiratory-deficient phenotype with loss of mtDNA Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
thiol-blocking agent
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm initially MIP synthesized as a large precursor molecule carrying a mitochondrial leader peptide Rattus norvegicus 5737
-
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-
mitochondrion
-
Schizophyllum commune 5739
-
mitochondrion after import of MIP in mitochondrion, processing of the precursor to the mature form by MPP Rattus norvegicus 5739
-
nucleus encoding of MIP Rattus norvegicus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information activated by divalent cations Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
-
Homo sapiens
75000
-
-
Rattus norvegicus
80000
-
-
Saccharomyces cerevisiae
80000
-
-
Schizophyllum commune

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Schizophyllum commune
-
-
-

Purification (Commentary)

Purification (Comment) Organism
affinity purified Saccharomyces cerevisiae
purified 2250fold to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-
liver
-
Rattus norvegicus
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in two-step processing of mitochondrial protein precursors Homo sapiens ?
-
?
additional information enzyme is involved in two-step processing of mitochondrial protein precursors Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
monomer
-
Homo sapiens
monomer
-
Rattus norvegicus
monomer
-
Saccharomyces cerevisiae
monomer
-
Schizophyllum commune

Synonyms

Synonyms Comment Organism
MIP
-
Mus musculus
MIP
-
Homo sapiens
MIP
-
Rattus norvegicus
MIP
-
Saccharomyces cerevisiae
MIP
-
Schizophyllum commune
MIP1
-
Saccharomyces cerevisiae
OCT1
-
Saccharomyces cerevisiae