Application | Comment | Organism |
---|---|---|
additional information | MIP stimulates iron uptake by mitochondria | Saccharomyces cerevisiae |
Cloned (Comment) | Organism |
---|---|
cloned into vector pG-3 | Saccharomyces cerevisiae |
expressed in Saccharomyces cerevisiae | Homo sapiens |
expressed in Saccharomyces cerevisiae | Rattus norvegicus |
expressed in Saccharomyces cerevisiae | Schizophyllum commune |
Protein Variants | Comment | Organism |
---|---|---|
additional information | disruption of the mouse MIP gene results in early embryonic lethality | Mus musculus |
additional information | when MIP is genetically inactivated, the protein is no longer processed to the mature form, resulting in a complex respiratory-deficient phenotype with loss of mtDNA | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
thiol-blocking agent | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | initially MIP synthesized as a large precursor molecule carrying a mitochondrial leader peptide | Rattus norvegicus | 5737 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
mitochondrion | - |
Schizophyllum commune | 5739 | - |
mitochondrion | after import of MIP in mitochondrion, processing of the precursor to the mature form by MPP | Rattus norvegicus | 5739 | - |
nucleus | encoding of MIP | Rattus norvegicus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | activated by divalent cations | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
75000 | - |
- |
Homo sapiens |
75000 | - |
- |
Rattus norvegicus |
80000 | - |
- |
Saccharomyces cerevisiae |
80000 | - |
- |
Schizophyllum commune |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Schizophyllum commune | - |
- |
- |
Purification (Comment) | Organism |
---|---|
affinity purified | Saccharomyces cerevisiae |
purified 2250fold to homogeneity | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
skeletal muscle | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme is involved in two-step processing of mitochondrial protein precursors | Homo sapiens | ? | - |
? | |
additional information | enzyme is involved in two-step processing of mitochondrial protein precursors | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | - |
Homo sapiens |
monomer | - |
Rattus norvegicus |
monomer | - |
Saccharomyces cerevisiae |
monomer | - |
Schizophyllum commune |
Synonyms | Comment | Organism |
---|---|---|
MIP | - |
Mus musculus |
MIP | - |
Homo sapiens |
MIP | - |
Rattus norvegicus |
MIP | - |
Saccharomyces cerevisiae |
MIP | - |
Schizophyllum commune |
MIP1 | - |
Saccharomyces cerevisiae |
OCT1 | - |
Saccharomyces cerevisiae |