Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Drosophila melanogaster | 5737 | - |
plasma membrane | - |
Drosophila melanogaster | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | P22817 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adult | highest expression in male adults | Drosophila melanogaster | - |
body wall | - |
Drosophila melanogaster | - |
brain | - |
Drosophila melanogaster | - |
fat body | highest expression | Drosophila melanogaster | - |
gut | - |
Drosophila melanogaster | - |
imaginal disc | - |
Drosophila melanogaster | - |
larva | - |
Drosophila melanogaster | - |
pupa | - |
Drosophila melanogaster | - |
salivary gland | - |
Drosophila melanogaster | - |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Drosophila melanogaster |
Insulin-degrading enzyme | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of enzyme function favors insulin resistance, a hallmark of diabetes mellitus type II. Down-regulation of the enzyme provokes reduction of tissue growth and sensitizes developmental timing and metabolism to high-sucrose diets | Drosophila melanogaster |
metabolism | the enzyme can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and promoting activation of Drosophila forkhead box, subgroup O transcription factor | Drosophila melanogaster |
physiological function | the enzyme provokes growth reduction mediated by the phosphatidylinositol-3-phosphate kinase pathway in a cell-autonomous manner | Drosophila melanogaster |