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Literature summary for 3.4.24.56 extracted from

  • Tundo, G.; Sbardella, D.; Ciaccio, C.; Bianculli, A.; Orlandi, A.; Desimio, M.; Arcuri, G.; Coletta, M.; Marini, S.
    Insulin-degrading enzyme (IDE): A novel heat shock-like protein (2013), J. Biol. Chem., 288, 2281-2289.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.56

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 x * 110000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid beta-peptide + H2O Homo sapiens
-
 ?
-
 ?
insulin + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14735
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
muscle
-
 Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta-peptide + H2O
-
 Homo sapiens ?
-
 ?
insulin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 110000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
IDE
-
 Homo sapiens
Insulin-degrading enzyme
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens all-trans retinoic acid treatment down-regulates enzyme expression in neuroblastoma cells down
Homo sapiens enzyme expression is stress-inducible (heat shock at 48°C for 15 and 30 min, increasing concentrations of H2O2, and serum starvation for 60 min) and up-regulated in some central nervous system tumors up

General Information

General Information Comment Organism
malfunction enzyme downregulation impairs SHSY5Y cell proliferation and triggers cell death. Enzyme inhibition is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates with proteasome and ubiquitin in SHSY5Y cells Homo sapiens