Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | a Zn2+ chelator | Homo sapiens | |
insulin-like peptide 3 | IDE degrades insulin quickly, and addition of INSL3 significantly decreases insulin degradation, competitive inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, overview | Homo sapiens | |
0.000052 | - |
Insulin | pH 7.7, 37°C | Homo sapiens | |
0.000055 | - |
insulin-like peptide 3 | pH 7.7, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on, IDE is a zinc-metalloprotease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | Homo sapiens | - |
amyloid beta peptide fragments | - |
? | |
insulin + H2O | Homo sapiens | - |
insulin peptide fragments | - |
? | |
insulin-like peptide 3 + H2O | Homo sapiens | IDE cleaves the peptide bond between R26 and W27 of the B-chain, and releases a pentapeptide, WSTEA, from the C-terminal of the B-chain | processed insulin-like peptide 3 + WSTEA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta + H2O | - |
Homo sapiens | amyloid beta peptide fragments | - |
? | |
insulin + H2O | - |
Homo sapiens | insulin peptide fragments | - |
? | |
insulin-like peptide 3 + H2O | IDE cleaves the peptide bond between R26 and W27 of the B-chain, and releases a pentapeptide, WSTEA, from the C-terminal of the B-chain | Homo sapiens | processed insulin-like peptide 3 + WSTEA | - |
? | |
insulin-like peptide 3 + H2O | IDE cleaves the peptide bond between R26 and W27 of the B-chain, and releases a pentapeptide, WSTEA, from the C-terminal of the B-chain, cleavage product identification by mass spectrometry, INSL-3 structure, overview | Homo sapiens | processed insulin-like peptide 3 + WSTEA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
Insulin-degrading enzyme | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
insulin-like peptide 3 | pH 7.7, 37°C | Homo sapiens | |
0.05 | - |
Insulin | pH 7.7, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.7 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | responsible for in vivo degradation of insulin, amyloid beta, and other peptide hormones, e.g. of insulin-like peptide 3, INSL3, an insulin superfamily peptide hormone, primarily expressed in the testes and playing a key role in the fetus testes descent and suppression of male germ cell apoptosis | Homo sapiens |