Crystallization (Comment) | Organism |
---|---|
analysis of the crystal structure of IDE active site, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent on, zinc metallopeptidase, simulated structures of the Zn2+ metal center, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta40 + H2O | Homo sapiens | Abeta40, an Alzheimer amyloid beta peptide | amyloid beta40 peptide fragments | - |
? | |
amyloid beta42 + H2O | Homo sapiens | Abeta42, an Alzheimer amyloid beta peptide | amyloid beta42 peptide fragments | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14735 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid beta40 + H2O | Abeta40, an Alzheimer amyloid beta peptide | Homo sapiens | amyloid beta40 peptide fragments | - |
? | |
amyloid beta40 + H2O | an Alzheimer amyloid beta peptide | Homo sapiens | amyloid beta40 peptide fragments | - |
? | |
amyloid beta42 + H2O | Abeta42, an Alzheimer amyloid beta peptide | Homo sapiens | amyloid beta42 peptide fragments | - |
? | |
amyloid beta42 + H2O | an Alzheimer amyloid beta peptide | Homo sapiens | amyloid beta42 peptide fragments | - |
? | |
additional information | active site structure of IDE, overview. Interactions of the two full-length Alzheimer amyloid beta peptides, Abeta40 and Abeta42, with the fully active form of IDE through unrestrained, all-atom molecular dynamics simulations, using free and small fragment-bound, Asp1-Glu3 and Lys16-Asp23 of Abeta40 and Asp1-Glu3 and Lys16-Glu22 of Abeta42, mutated forms of IDE and NMR structures of the full-length Abeta40 and Abeta42, overview. In comparison to Abeta40, Abeta42 is more flexible and interacts through a smaller number, 17-22, of hydrogen bonds in the catalytic chamber of IDE. Both the substrates adopt more beta-sheet character in the IDE environment. Hydrogen bonding interactions between IDE and substrates amyloidbeta40 and amyloidbeta42, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDE | - |
Homo sapiens |
insulin degrading enzyme | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | IDE catalyzes the degradation of the monomeric forms of Alzheimer amyloid beta peptides, which is critical for preventing the progression of Alzheimer's disease, overview | Homo sapiens |